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[–]voltagegate20 points
4 points
4 points
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ago
(edited ago)
I am a bioinformatics researcher specializing in non-coding RNA research. First of all, the amount and duplication of genomic material doesn't strongly correlate with organism complexity. Otherwise, the world would be ruled by humble japanese flower plants and amoebas I guess.
But even if you assumed that it does, did you know that only one X chromosome in females is even expressed through the majority of the human life cycle? After embryonic development, a non-coding gene called XIST completely coats the paternal X chromosome, inactivating it. The paternal X chromosome is not expressed in adult women... except for one particular case: cancer. In fact, transcriptional leakage of the paternal X chromosome is a biomarker of breast cancer in women.
[–]european[S]0 points
1 point
1 point
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ago
did you know that only one X chromosome in females is even expressed through the majority of the human life cycle?
I did not,
i seem to be misinformed , i was led to believe that having 2 x was an advantage. i.e things like x linked diseases occur in males but carried by female.
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[–] voltagegate2 0 points 4 points 4 points (+4|-0) ago (edited ago)
I am a bioinformatics researcher specializing in non-coding RNA research. First of all, the amount and duplication of genomic material doesn't strongly correlate with organism complexity. Otherwise, the world would be ruled by humble japanese flower plants and amoebas I guess.
But even if you assumed that it does, did you know that only one X chromosome in females is even expressed through the majority of the human life cycle? After embryonic development, a non-coding gene called XIST completely coats the paternal X chromosome, inactivating it. The paternal X chromosome is not expressed in adult women... except for one particular case: cancer. In fact, transcriptional leakage of the paternal X chromosome is a biomarker of breast cancer in women.
[–] european [S] 0 points 1 point 1 point (+1|-0) ago
I did not,
i seem to be misinformed , i was led to believe that having 2 x was an advantage. i.e things like x linked diseases occur in males but carried by female.