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[–] Dysnomia 0 points 12 points (+12|-0) ago 

The Metroid e-manga covers Samus's origins. She was born and raised on the mining planet K-2L, and when she was a child, the planet was raided by Space Pirates, led by Ridley, in an attack that killed both her parents and destroyed the planet. The orphaned Samus was then found by a bird-like alien race known as the Chozo, who brought her to their home planet Zebes. Samus was infused with Chozo DNA to give her a strong resistance to foreign environments, then trained as a warrior and given one of the alien race's artifacts, the Power Suit.

The series' co-creator Yoshio Sakamoto recalled, "We were partway through the development process when one of the staff members said 'Hey, wouldn't that be kind of cool if it turned out that this person inside the suit was a woman?'"[14] The developers voted on the concept, and it passed.[8] The game's instruction manual refers to Samus as if she were male to keep her true gender a secret until the end of the game.[7] Sakamoto noted that during the course of the Metroid series, developers constantly try to express Samus's femininity without turning her into a sex object.

https://en.wikipedia.org/wiki/Samus_Aran

Yup. Samus is trans alright. Transgenically modified.

Samus was infused with Chozo DNA