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[–] Wolf451 0 points 3 points (+3|-0) ago 

According to Wikipedia there was a vaccine attempt for the 1917 “Spanish Flu”

“In the worldwide Spanish flu pandemic of 1918, "Physicians tried everything they knew, everything they had ever heard of, from the ancient art of bleeding patients, to administering oxygen, to developing new vaccines and serums (chiefly against what we now call Hemophilus influenzae – a name derived from the fact that it was originally considered the etiological agent – and several types of pneumococci). Only one therapeutic measure, transfusing blood from recovered patients to new victims, showed any hint of success."[183]

https://en.m.wikipedia.org/wiki/Influenza_vaccine

The history of vaccines back well into the 18th century...

“The smallpox vaccine was the first vaccine to be developed against a contagious disease. In 1796, the British doctor Edward Jenner demonstrated that an infection with the relatively mild cowpox virus conferred immunity against the deadly smallpox virus.”

https://en.m.wikipedia.org/wiki/Smallpox_vaccine