[–] Rotteuxx 0 points 5 points (+5|-0) ago 

Conclusions: These SARS-CoV vaccines all induced antibody and protection against infection with SARS-CoV. However, challenge of mice given any of the vaccines led to occurrence of Th2-type immunopathology suggesting hypersensitivity to SARS-CoV components was induced. Caution in proceeding to application of a SARS-CoV vaccine in humans is indicated.

The vaccines work... when they don't make you hyper susceptible to cytokine storms. Did I read that right?

[–] JesusRules [S] 0 points 1 point (+1|-0) ago 

Maybe, also the antibodies against an antigen in the Sars vaccine have cross-reactivity with lung cells, auto-immunity?

[–] Rotteuxx 0 points 2 points (+2|-0) ago 

Th1-type cytokines tend to produce the proinflammatory responses responsible for killing intracellular parasites and for perpetuating autoimmune responses. Interferon gamma is the main Th1 cytokine. Excessive proinflammatory responses can lead to uncontrolled tissue damage, so there needs to be a mechanism to counteract this. The Th2-type cytokines include interleukins 4, 5, and 13, which are associated with the promotion of IgE and eosinophilic responses in atopy, and also interleukin-10, which has more of an anti-inflammatory response. In excess, Th2 responses will counteract the Th1 mediated microbicidal action. The optimal scenario would therefore seem to be that humans should produce a well balanced Th1 and Th2 response, suited to the immune challenge.


Umh... it makes your body release more th2 thingamajigs which hinder the proper immune response to the infection?

I dunno m8, I'm just a welder nearing his bedtime.