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[–] kolabr 0 points 18 points (+18|-0) ago 

These compounds, called GABA-NAMs, minimize unwanted side effects because they are precise: they work only in the parts of the brain that are essential for mood.

GABA receptors are inhibitory in mature adult brains but excitatory in developing brains. I would imagine that if any prescription came from this class of drugs, it would be very age restricted. In addition, I am very skeptical of the above statement saying that the inhibitors are precise. I wonder what side effects will become apparent in future trials. Sounds like their discovery is very preliminary.

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[–] Doxy 0 points 5 points (+5|-0) ago  (edited ago)

They are negative allosteric modulators. There's a principal substance that binds to every receptor in the body. This is called an orthosteric substance. Allosteric substances are substances that bind to a site different from the orthosteric substance in the same receptor. So GABA-NAMs bind to a site different from GABA in the GABA receptors. When they bind to the receptor they cause a change in the receptor, reducing the intensity of the interaction between GABA and its receptor.

Now, the interesting part about allosteric modulators is that they have no effect in the absence of the orthosteric ligand. Thus, in the brain regions where there is no GABA to modulate, the GABA-NAMs will have no effect, so this is where GABA-NAMs' specificity comes from.

Edit: I just wanted to add, of course there must be a strict age restriction. When SSRIs first were released -specially fluoxetine- , there was a sudden increase in suicide rates amongst teens using them. This was not foreseen, and as always, clinical research is obligatory for the release and the dosing of a drug.

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[–] ShinyVoater 0 points 1 point (+1|-0) ago 

If the claims of pretty much instant relief and no effect in the non-afflicted pan out, it sounds like it could serve as a useful diagnostic tool in something like a seven-day course, even if there's a horror show of side effects from long-term use. The magical happy pills not working would serve as concrete proof that could possibly save millions in health care costs from unnecessary medication and the complications thereof.

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[–] Doxy ago 

A fun fact I just remembered: progesterone has a metabolite called allopregnenanolone. This is a neurosteroid, that is, a steroidal hormone with effects on the central nervous system. It also acts as a negative allosteric modulator for GABA1 receptors, reducing GABA action. The abnormal GABA regulation, consequence of decreased neurosteroid levels during the premenstrual period, has been proposed as a possible mechanism for the premenstrual syndrome. Here's a (free) article regarding GABA neurotransmission and depression.

For anyone interested in the neurotransmission pathways involved in depression, here's an extensive and comprehensive review (also free) about the mechanisms and therapeutic interventions for depression.

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[–] usableclown 0 points 2 points (+2|-0) ago 

It's about time! Current ssri antidepressants are not good drugs. I can't think of too many side effects worse for a depressed man than making his cock not work right

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[–] CommonSense 0 points 2 points (+2|-0) ago 

I know of a plant that treats depression within 24 seconds.

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[–] Broda 7 points 2 points (+9|-7) ago 

We have had something better though since...well, forever. Weed. It works for so many things and we still treat it like its so bad and make all these other chemical compounds. Not trying to be an ass but it worked pretty well for me when i was depressed.

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[–] gbj1301 0 points 9 points (+9|-0) ago  (edited ago)

Did not work for me, first of all mild hallucinogenic effects did not play well with my depression and I got quite the paranoia the few times I tried it. SSRIs have however worked quite well on me. But use what works for you. The worst thing you can do is not to seek help from a professional.

Edit: Spelling is hard

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[–] Broda 0 points 4 points (+4|-0) ago 

what works for some dosnt always work for all i guess. My dad always hated smoking pot bc it made him feel nervous and he described feeling liek he had the flu.

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[–] sneakybells 0 points 2 points (+2|-0) ago 

What type of weed are you smoking that is mildly hallucinogenic?

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[–] Kloocle 0 points 2 points (+2|-0) ago 

And as a painkiller it works pretty well too.

[–] [deleted] 0 points 1 point (+1|-0) ago 

[Deleted]

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[–] Broda ago 

you just generally disagree?

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[–] Bainshie 3 points 1 point (+4|-3) ago 

Downvoated because the "Weed cures everything ever" community is fucking retarded. If you "cured" your depression with weed, then you weren't depressed.

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[–] CommonSense 1 point 4 points (+5|-1) ago 

They didn't say it cures everything. They didn't say it cures anything. You've got a bad attitude, my friend. No worries though. I'm not going to downvote you just because I disagree with your douchey perspective.

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[–] Broda 0 points 2 points (+2|-0) ago 

Your confusing cured with treats. I dont even smoke but it really does seem to help a lot of people. Plus its natural.

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[–] navybill1984 0 points 2 points (+2|-0) ago 

This does look pretty interesting. As someone who has to take anti depressants, this could be something worth trying. Not that I'm expecting a miracle cure for depression or anything, but it would be something to see how it works.

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[–] Doxy ago  (edited ago)

What kind of antidepressants are you on? Do you experience a lot of side effects? I know SSRIs are not free of side effects, but I consider they have a decent tolerability, that's why I am asking. The biggest disadvantage of SSRIs (and any every other antidepressant) is the long time it takes for their onset of action, which may lead to decreased adherence by the patients.

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[–] IveSeenYouNakid 0 points 1 point (+1|-0) ago 

"Exericise"

[–] [deleted] 0 points 1 point (+1|-0) ago 

[Deleted]

[–] [deleted] 0 points 1 point (+1|-0) ago 

[Deleted]

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[–] sneakybells 0 points 1 point (+1|-0) ago  (edited ago)

I'm going to be going to a ketamine clinic soon, supposedly it's amazing for depression and you only Have to do a few sessions.

[–] [deleted] ago 

[Deleted]

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[–] larcher 0 points 1 point (+1|-0) ago 

GABA negative allosteric modulators? Won't they cause anxiety and increase the risk of seizures?

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[–] ezdi ago 

Near as I can tell from the press release, this is basically alcohol-lite. So the anxiety and seizure risk would only show up upon discontinuing.

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[–] larcher 0 points 1 point (+1|-0) ago 

Their proposed class of drugs is GABA-NAM (GABA negative allosteric modulator) while ethanol is a positive allosteric modulator of GABA. GABA PAMs like ethanol, benzos, barbs etc should decrease anxiety and susceptibility to seizures so at first I also thought it would be something like that but apparently they are trying to increase excitatory activity using GABA-NAMs and I was under impression they are really unsafe.

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