At the end of Kali Yuga, when there exist no topics on the subject of God, even at the residences of so-called saints and respectable gentlemen, and when the power of government is transferred to the hands of ministers elected from the evil men, and when nothing is known of the techniques of sacrifice, even by word, at that time the Lord will appear as the supreme chastiser.
— Bhagavata Purana, 2.7.38
When the practices taught in the Vedas and institutes of law have nearly ceased, and the close of the Kali age shall be nigh, a portion of that divine being who exists of His own spiritual nature, and who is the beginning and end, and who comprehends all things, shall descend upon earth. He will be born in the family of Vishnuyasha, an eminent brahmana of Shambhala village, as Kalki, endowed with eight superhuman faculties, when the eight suns (represented by 8 solar deities or Vasu who lord over Dhanishta Nakshatra) will together shine over the sky. By His irresistible might he will destroy all the mlecchas (Barbarians) and thieves, and all whose minds are devoted to iniquity. He will reestablish righteousness upon earth, and the minds of those who live at the end of the Kali age shall be awakened, and shall be as clear as crystal. The men who are thus changed by virtue of that peculiar time shall be as the seeds of human beings, and shall give birth to a race who will follow the laws of the Krita age or Satya Yuga, the age of purity. As it is said, 'When the sun and moon, and the lunar asterism Tishya, and the planet Jupiter, are in one mansion, the Krita age shall return.
— Vishnu Purana, Book Four, Chapter 24
The name Kalki is derived from the Sanskrit word kalā (कला) which means any practical art, any mechanical or fine art. The closest word in Greek is techne, the root for today's English word of Technology. The ki in Kalki means made of, or made from, signifying that Kalki will be made of the mechanical or technological arts.
The name Kalki may be a metaphor for eternity or time as kalā has the secondary meaning of a part ( of anything) including time or atoms.
Within the mammalian family, there are four well defined groups of Pax genes.
Pax group 1 (Pax 1 and 9),
Pax group 2 (Pax 2, 5 and 8),
Pax group 3 (Pax 3 and 7) and
Pax group 4 (Pax 4 and 6).
Orthologous genes exist throughout the Metazoa, including extensive study of the ectopic expression in Drosophila using murine Pax6.
PAX1 has been identified in mice with the development of vertebrate and embryo segmentation, and some evidence this is also true in humans. It transcribes a 440 amino acid protein from 4 exons and 1,323bps in humans.
PAX2 has been identified with kidney and optic nerve development. It transcribes a 417 amino acid protein from 11 exons and 4,261 bps in humans. Mutation of PAX2 in humans has been associated with renal-coloboma syndrome as well as oligomeganephronia.
PAX3 has been identified with ear, eye and facial development. It transcribes a 479 amino acid protein in humans. Mutations in it can cause Waardenburg syndrome. PAX3 is frequently expressed in melanomas and contributes to tumor cell survival.
PAX4 has been identified with pancreatic islet beta cells. It transcribes a 350 amino acid protein from 9 exons and 2,010 bps in humans.
PAX5 has been identified with neural and spermatogenesis development and b-cell differentiation. It transcribes a 391 amino acid protein from 10 exons and 3,644bps in humans.
PAX6 (eyeless) is the most researched and appears throughout the literature as a "master control" gene for the development of eyes and sensory organs, certain neural and epidermal tissues as well as other homologous structures, usually derived from ectodermal tissues.
PAX7 has been possibly associated with myogenesis. It transcribes a protein of 520 amino acids from 8 exons and 2,260bps in humans. PAX7 directs postnatal renewal and propagation of myogenic satellite cells but not for the specification.
PAX8 has been associated with thyroid specific expression. It transcribes a protein of 451 amino acids from 11 exons and 2,526bps in humans.
PAX9 has found to be associated with a number of organ and other skeletal developments, particularly teeth. It transcribes a protein of 341 amino acids from 4 exons and 1,644bps in humans.
NKX-homeodomain factors are a family of homeodomain transcription factors that are critical regulators of organ development.
Human genes that encode NKX-homeodomain factors include:
NKX2-1, NKX2-2, NKX2-4, NKX2-8
NKX6-1, NKX6-2, NKX6-3
Homeobox protein DBX1, also known as developing brain homeobox protein 1, is a protein that in humans is encoded by the DBX1 gene
Iroquois homeobox factors are a family of homeodomain transcription factors that play a role in many developmental processes.
Human genes that encode Iroquois homeobox factors include:
IrxA sub-group: IRX1, IRX2, IRX4
IrxB sub-group: IRX3, IRX5, IRX6
Iroquois-like gene: MKX