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[–] Hand_of_Node 0 points 1 points (+1|-0) ago 

First defense is not getting in that situation in the first place. But then you have to use your judgement as to whether you'd just enrage your attacker, or whether you could plausibly pull off a defense. If you think you're going to end up dead, it's probably worth trying to do some damage.

This is a whole topic that can't really be covered in a comment.