I was playing a nice game of Cards Against Humanity at my friends place when the one fatty at the party joins in, a girl who needed to lose a healthy 80 pounds. After a round or two I get a gift from the gods: I draw the white card Being fat and stupid. As soon as I pick this up I know I'm saving it for her turn and playing it no matter what.
So her turn comes around and she plays a black card - I forget which one but my Being fat and stupid card fits perfectly. I slam it down, feeling giddy with anticipation and wait for her to start reading them. She gets through a couple cards, then suddenly gets a shocked expression and I can tell she's gotten to my card. I make eye contact with my friend across the table and pointed to myself so he knows I'm calling it.
She hesitantly reads out loud "Being fat and stupid". Huge response - everyone human-sized at the table cracks up.
Now for the best part you guys: All the other answers were crap so she pretty much has to pick my card since it got the biggest laugh. I get to look her in her piggy eyes as she hands me my prize and it dawns on her that she just got shitlorded via CAH and has to take it. I see shame, hurt, and lingering confusion - delicious.