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[–] 14783708? 0 points 6 points (+6|-0) ago 

It's important to keep in mind that synthetic molecules are frequently not identical to the biologically created molecule. Additionally, biological samples can also have closely related variants of the same molecule which can compliment each other in both uptake and function. Which may be entirely absent in the synthetic variant.

Also, synthetic and biological sources frequently have different uptakes with consumption simply because their molecules are slightly different in shape. As such, the human body may simply refuse to use it. This is why, for example, thyroid is available from both synthetic and biological sources. Also worth pointing out that biological sources frequently vary dramatically in potency. Which is the primary reason synthetic is frequently preferred over that of biological sources.

Biological sources are almost always superior to that of synthetic variants. In some cases the synthetic source is completely rejected by the consumer. Some thyroid patients are entirely unable to use synthetic.