I'm all for it. Flamenco? Invented in Barcelona. Rumba Flamenca? Also, Barcelona. El Bulli(formerly the "best restaurant in the world")? Barcelona. Barcelona is one of the coolest cities in the world, and Madrid wants to control it. and keep all of the money it makes.
The only reason Catalonia is even part of Spain is because it was part of Franco's little empire. They don't even speak the same language.
I play guitar as a hobby, and one site I go to from time to time is tocamela.cat. I want some Spanish-speakers to scroll down a bit until you see a paragraph, then read it and tell me that's fucking Spanish. It's not. The site is bilingual, and you can choose "Castellà" in the upper right hand corner.
I'm all for it. Look at a map and you'll notice that Catalonia surrounds the Basques. Guarantee that an autonomous Catalonia will do way better by the Basques than Madrid has.
It's their region, their culture, let 'em have it. Madrid loses some tax dollars and some vicarious notoriety. BFD.
edit: someone is downvoating everyone who comments here. You're getting one up from me, at least, and that brings you to zero. Sorry that some people are assholes..
edit2: my daughter is going to Barcelona in a couple of weeks on a trip planned before all of this went down. I told her she's probably going into a civil war and police-state riots. I also told her that if she hits a cop, make sure it's a Madrid/Spain cop, and not a Barcelona cop. She said "duh." I hope she doesn't get hurt. My baby is one seriously bad-ass chick, but she's reckless and I'm worried.