[–] qwop 0 points 1 point 1 point (+1|-0) ago (edited ago)
This is a good question. It is also explained a little bit towards the end of the video with the rat study and the GM peas. In the end they found that the GM peas produced a protein that had never existed before (but produced by nature none the less), and it was so toxic that they had to abort the whole project.
So yes you could call the protein "natural", as in "produced by nature", but it is also "unnatural", because nature would never have produced it in the first place, unless it was forced by man.
Forcing nature to do things which it would not do under normal circumstances, is at least for me what puts something like that in the "unnatural" category.
I hope that helps a little bit. So yes, it is possible to make nature do things it would not normally do, and in some cases, if we are not careful, it could be the Pandora's box like you say.