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[–] SecretSquirrel ago 

I lost my save for Oblivion years back right before the Shivering Isles expansion came out and it was the worst thing ever

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[–] dootdootcalcium ago 

I can think of so many. Minecraft, Oblivion, Skyrim, really any RPG I'd say.

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[–] deathlogic ago 

any game that has unlock-able content. I remember losing my SSB melee file after unlocking every character and completing all the event matches. I was kinda done with that one for a while lol.

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[–] JosephIsABroseph ago 

Monster Hunter 4 Ultimate definitely. it could take anywhere from 300 to 800 hours to have good endgame weapons or armor sets.

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[–] DrBunsen ago 

any game, I wont play a game anymore after loosing a safe

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[–] peter_file ago 

Pokemon on the Gameboy. I traded so much with other people at school and on vacations. Until that one time my little brother accidentally overwrote it with a new game.

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[–] NassTee ago 

GTA San Andreas. Oh, you just want to go fly around in a plane for a while? Nope, you're going to do all the missions again first, else we'll shoot you if you leave Los Santos.